The invention discloses a composite spouted flue gas purification method based on pollutant combined removal, relating to a flue gas purification method and solving the problems that traditional flue gas control technology is a single removal technology specific to a single pollutant of SOX or NOx, and same equipment is utilized to hardly remove the SNX, the NOx, harmful heavy metal and ultrafineparticles simultaneously. The method is carried out based on a single reaction tower. In the method, two functional zones are formed by axially grading a reaction process inside the reaction tower along a flue gas running direction, wherein the two functional zones are a first grade spout reaction zone and a second grade spout reaction zone which are arranged inside the single reaction tower frombottom to top; the first grade spout reaction zone is a main gas-liquid reaction zone and used for removing the SOX and NOX; and the second grade spout reaction zone is a main gas-solid reaction zoneand used for removing the harmful heavy metal and the clustered ultrafine particles. The invention realizes an integral combined removal of a plurality of flue gas pollutants of the SOX, the NOX, heavy metal pollutants, ultrafine particles, and the like, wherein flue gas desulfuration rate can reach above 90 percent, and the removal rate of the ultrafine particles and the heavy metals can reach above 90 percent when matching with an electric precipitator.