The invention relates to the field of medicine and discloses a fat-reducing medicine, comprising extracts of notoginseng, ginkgo leaves, kudzu roots, red sage roots and red peony roots and polysaccharide-peptide. The weight ratio of the notoginseng to ginkgo leaves to kudzu roots to red sage roots to red peony root to polysaccharide-peptide is 1: (1 to 4): (0.5 to 2): (1 to 4): (0.5 to 2): (0.05 to 0.4). The raw material is extracted by a water extraction method or an alcohol extraction method, and is absorbed and purified through macroporous resin. The medicine is suitable to prepare medicines for curing hyperglycemia, fat liver or Alcoholic fatty liver.