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发明授权
CN101723385B 一种标记放射性核素125I的纳米二氧化硅颗粒及其制备方法 失效 - 权利终止

一种标记放射性核素125I的纳米二氧化硅颗粒及其制备方法
摘要：
本发明涉及一种标记放射性核素的纳米二氧化硅颗粒及制备方法，所述的纳米二氧化硅颗粒可由下述方法制备获得，其步骤为：(a)硅烷偶联剂对纳米二氧化硅颗粒的改性；(b)125I-BH标记物的制备；(c)125I-BH标记物与改性的纳米二氧化硅颗粒连接。本发明选用化学活泼性高的放射性核素125I，它具有合适的半衰期，为60天，可以用于纳米二氧化硅颗粒体内显像和生物学分布研究，使放射性污染易于控制和处理。放射性核素125I可以发射γ射线，穿透力强，可以定量和直观的检测纳米二氧化硅颗粒的体内生物学分布和显像。
摘要（英）：

The invention relates to a nanometer silicon dioxide particle for marking a radionuclide 125I and a preparation method thereof. The method for preparing the nanometer silicon dioxide particle comprises the following steps of: (a) modifying the nanometer silicon dioxide particle with a silane coupling agent, (b) preparing a 125I-BH label, and (c) coupling the 125I-BH label with the modified nanometer silicon dioxide particle. The radionuclide 125I of the invention has a high chemical activity and a proper half-life period (60 days), and can be used for researching biological distribution and display in the nanometer silicon dioxide particle, so the radioactive pollution is easy to control and treat. The radionuclide 125I can emit Gamma ray, has high penetrating power, and can quantitatively and intuitively detect the in vivo biological distribution and display of the nanometer silicon dioxide particle.

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