The invention relates to a method for comprehensively manufacturing biomass, and effectively solves the problems of difficult dust removal, poor adaptability and poor economy of raw materials existing in the method for physically and chemically manufacturing the biomass. The method comprises the following steps: performing cracking reaction on the biomass to generate charcoal and pyrolysis gas after the biomass is crushed; cooling and separating the pyrolysis gas into gas and liquid after the pyrolysis gas is subjected to dust removal; introducing cooled gas into a gasometer to be used as fuel of a cracking furnace; feeding the liquid to a fractionating column for separation; separating tar from the column bottom to be used as fuel of the cracking furnace or to be manufactured into liquidfuel or other chemical products; separating light liquid wood vinegar liquid from the column top; feeding the wood vinegar liquid into a liquid storage tank for storing, or mixing and composting the wood vinegar liquid with crushed straws; and carrying out anaerobic digestion to generate biogas, biogas residue and biogas slurry after the composted straws and organic waste or domestic sewage are mixed and regulated so as to realize comprehensive manufacture and utilization of the biomass. The method has simple process, cleanness, energy conservation, environmental protection, tremendous economic and social benefits, and is innovation in the field of biomass energy.