The invention relates to a solid medium contained plunger pump stuffing sealing device which comprises a plunger, a main stuffing press cover, a stuffing body, an outlet one-way valve, a flushing fluid pipe, an auxiliary stuffing press cover, an auxiliary stuffing box, an O-shaped ring, an inlet one-way valve, a main stuffing box, a flushing fluid guide ring and an isolated body. The stuffing body is coated at the periphery of the plunger, the front end of the stuffing body is connected with a pump head, the rear end is connected with a power part, the isolated body is arranged between the inside of the stuffing body and the plunger, the isolated body is of a tooth slot-shaped structure, and the flushing fluid guide ring is arranged behind the isolated body. The stuffing body and the plunger are sealed through the main stuffing box, the main stuffing box is compressed through the main stuffing press cover, the main stuffing press cover is in threaded connection with the stuffing body, and the main stuffing press cover is sealed through an O-shaped seal ring. The main stuffing box is a plurality of groups of stuffing which is formed by alternately assembling a packing and a lined ring, and performs an absolute sealing action on a pump conveying medium. The main stuffing press cover and the plunger are sealed through the auxiliary stuffing box, and the auxiliary stuffing box is compressed through the auxiliary stuffing press cover.