The invention relates to a biological characteristic point topological structure-based random number generator, in particular to a biological characteristic point topological structure-based random number manufacturing method. The invention aims to provide a random number generator for generating information containing a biological characteristic point topological structure. The method is technically characterized by comprising the following steps: setting an input interface to connect a G data acquisition module to acquire G variable data, setting a step of performing program data structured processing for input biological characteristic point topological structure matrix data and assigning the G for the G data acquisition module, setting an input interface to connect a K acquisition module to acquire K variable data, setting the traditional random number generator in the K acquisition module, performing random displacement and rotating operation processing for the input G data and the K according to a formula that GK is equal to P, and splicing point coordinate parameters of the P data in turn to form a random number containing the a biological characteristic point topological structure information for an authenticated key.