The embodiment of the invention relates to a method for managing user personalized information in a digital photo frame and a digital photo frame. The method comprises the following steps: receiving the input user identification information; comparing the consistency of the input user identification information and the registered user identification information, and if so, displaying the interactive interface of the digital photo frame at least containing the file write function; receiving a user file sent by an external storage device according to the file write command input on the interactive interface; and storing the received user file and the user identification information in an associative memory. When a plurality of users use the same digital photo frame, the invention can call corresponding system setup parameters and private contents for different users, thereby protecting the personal information and enhancing the personalized experience of users.