The invention discloses a preparation method of a bitter-free azithromycin granular composite, which comprises the following steps: weighing azithromycin according to the weight ratio of gelatin and azithromycin being 0.01-1:1, then adding gelatin solution into the azithromycin, granulating, drying and grinding to prepare the azithromycin gelatin granule; adding sodium chloride solution into the azithromycin gelatin granule, and drying to prepare the azithromycin inclusion compound; and adding cane sugar, preglatinized starch, sodium carboxymethylcellulose, polyvidone K30 aqueous solution andorange essence into the azithromycin inclusion compound to prepare the bitter-free azithromycin granular composite. The invention can mask the bitter taste of azithromycin to realize an unexpected effect, after packaging, the azithromycin granule prepared by adding with cane sugar, saccharin sodium, orange essence and the other pharmaceutical excipients has sweet taste and fragrant scent, basically has no bitter taste, and is particularly suitable for being taken by children. The preparation method is simple, the cost is low, and the industrialized production is feasible.