The invention relates to a medicine composition for treating acute and chronic aryngitis and a preparation method thereof. The medicine composition comprises corticosteroids, inflammation-diminishing preservative with inflammation-diminishing sterilizing function, glycyrrhizic acid traditional Chinese medicines with anti-inflammatory and antianaphylaxis and cough-relieving function, menthol crystal and the like. The medicine composition is characterized by comprising 0.05-0.5 percent of corticosteroids, 0.015-0.15 percent of inflammation-diminishing preservative and 0.05-0.5 percent of glycyrrhizic acid traditional Chinese medicines. Preparations of the medicine composition comprise spray, nose drops, oral solutions, oral tablets, granules and the like, preferably, the spray or nose drops or oral tablets. The preparation method of the spray comprises the following steps of: dissolving surfactant by using distilled water, dropping a proper amount of Tween 80; stirring for dissolving, respectively adding a corticosteroids water solution, a glycyrrhizic acid traditional Chinese medicines water solution and a proper amount of menthol crystal water solution, and ultrasonically mixing uniformly. The traditional Chinese medicine and western medicine compound spray or nose drops for treating the acute and chronic aryngitis have scientific formula, convenient use, high local medicine concentration and accurate clinical treatment effect.