The invention relates to a waterproof, air-permeable, skidproof and cushioning combined shoe sole with multilayered structure, which is used for casual shoes, travel shoes, sports shoes, leather shoes and the like. The shoe sole consists of an outsole, a waterproof and air-permeable component and an air-permeable midsole arranged from bottom up. The outsole is provided with air-permeable sections at least at the position corresponding to the sole and/or heel of people; several bending segments protruding towards the top surface of the outsole are formed at the air-permeable sections of the outsole and are parallel with each other at interval; every two bending segments are connected by means of a plane part; the bending segments divides the outsole into a lower air storage space in communication with the lower surface of the outsole, and an upper air storage space in communication with the waterproof and air-permeable component; and the bending segment is provided with air-permeable holes capable of communicating the lower air storage space with the upper air storage space. The air-permeable holes are parallel to the surface of the outsole so that the shoe sole is skidproof and cushioning and effectively prevents foreign matters from piercing the waterproof and air-permeable component.