The invention discloses a medicament composition for preventing and controlling restenosis after intracoronary stent implantation and a preparation method thereof. The medicament composition is prepared from raw materials of black bean, radix puerariae and hirudo. The preparation method of the medicament composition comprises the following steps of: cooking black beans at high temperature; carrying out countercurrent extraction to obtain dry nattokinase powder after fermenting inoculated bacillus subtilis natto; carrying out reflux extraction of the radix puerariae with ethanol with the temperature of 80 DEG C, concentrating and drying to obtain dry total flavonoid powder of the radix puerariae; carrying out reflux extraction of the hirudo with ethanol and recovering the ethanol to obtainhirudin; and mixing the three components and filling into sustained-release capsules to obtain the medicament composition. The invention has the obvious functions of thrombolysis, anticoagulation andinhibition of vascular smooth muscle proliferation and can effectively prevent and control restenosis after intracoronary stent implantation. In addition, the invention has the advantages of low price, quick action, durable time, little toxic or side effect, simple process and low cost and energy consumption, thereby being suitable for industrialized production.