The invention discloses a bubble-free transfusion system, which comprises a bottle stopper puncture outfit, an air filter, a drip hopper, a flow regulator, a disposable intravenous needle and the like and is characterized in that an anti-bubble liquid dropping device consists of a dropper body, a dropper body holder and a dropper body connecting conduit. In the normal transfusion process, the anti-bubble liquid dropping device makes the pressure in the drip hopper and the external air pressure reach a critical balance state, and simultaneously, height differential pressure is formed between aliquid inlet hole on the dropper body and the top end of a liquid inlet needle, so gas and liquid can not flow out simultaneously, which ensures that no bubble exists in the transfusion process. The invention has the following advantages: 1 the bubble removing performance is stabler; 2 the drip hopper does not need to be extruded in the use process; 3 the entire transfusion operation step is simple without any additional steps; 4 no liquid medicine is left in the drip hopper when transfusion is ended; and 5 the bubble-free transfusion system is very favorable for rapid transfusion in an emergency state and strives for time for rescuing serious patients.