The invention discloses an ethionine resistance Candida utilis and application thereof, wherein the Candida utilis SUGS-01 is preserved in China Center for Type Culture Collection (CCTCC) on December 9th, 2009, and the preservation number is CCTCC M 209298. The Candida utilis SUGS-01 is applied to produce SAM and GSH by co-production and fermentation, and the application comprises the following steps: taking the Candida utilis SUGS-01 as the original strain, and after slant culturing and seed culturing, fermenting for at least 24 hours; one litre of fermentation medium contains 35-36g of canesugar, 10-12g of ammonium sulfate, 12-13g of monopotassium phosphate, 0.05-0.06g of magnesium sulfate and 4-5g of L-methionine; and the pH value of the fermentation medium is 5.5-6.0. Because adopting the combined action of UV mutagenesis and gamma-ray mutagenesis, the invention obtains the Candida utilis mutant strain which can co-produce SAM and GSH, and the obtained Candida utilis is used as production strains, has the advantages of wide growth nutrition spectrum, less production of ethanol during the fermentation process, strong capability to synthesize protein and the like, and has good industrial application prospect.