The invention discloses a manufacturing method of the wheel center of a dehumidification rotating wheel. The method comprises the following steps of: firstly, mixing powdered materials capable of adsorbing liquid water with binder, suspending agent solid and water to form a sizing agent; secondly, coating the sizing agent obtained on a carrier; thirdly, thermally pressing the carrier coated with the sizing agent to a corrugated shape; rolling or folding the obtained corrugated carrier into a wheel center and baking; and finally placing the obtained wheel center into a LiCL solution for soaking to obtain the final wheel center. The wheel center obtained by adopting the method has stronger moisture absorption performance, and practice proves that the air processing effect is very obvious by adopting the wheel center of the dehumidification rotating wheel. The moisture content and the dew-point temperature of output air of damp air processed by the wheel center are both very low, therefore, the invention can be widely applied to the field of air dehumidification and replace the traditional fixed rotating wheel dehumidification and liquid spraying dehumidification.