The invention provides a Chinese traditional medicine combination for alleviating wound infections and suture reaction after surgery and a preparation method thereof. The Chinese traditional medicine combination comprises 20-45% of Ligusticum wallichii, 20-45% of radix angelicae and 20-45% of rheum officinale, and antiseptic and sarcogenic traditional Chinese medicine can be added. The preparation method of the Chinese traditional medicine combination is as follows: soaking the Ligusticum wallichii, the radix angelicae and the rheum officinale in plant oil, heating and boiling, and then filtering to get the filtrate, i.e. the medical oil. In addition, excipient can be added to the filtrate to prepare the filtrate to be a form of drug. The Chinese traditional medicine combination can effectively curb wound infections after surgery, accelerate the healing of the wound and alleviate suture reaction after surgery. The preparation method of the Chinese traditional medicine combination is simple and easy to carry out.