The invention relates to a water base lubricating agent used for eccentric wear prevention of an oil well, which is applied to prevent eccentric wear for oil well oil extraction or slow down eccentric wear of the oil well and comprises the following components in percentage by weight: 3.5-5.0% of polyoxyethylene glycerol borate stearic acid ester, 3-3.5% of fatty acid imidazoline borate, 4.5-7.0% of amphoteric surfactant SS-Z, 0.005-0.01% of fluorocarbon surfactant FN-2, 0.1-0.25% of vitamin C, 11.5-14.5% of polyoxyethylene alkyl phenol ether sulfonic acid sodium salt and the balance of water; and the total weight percent of the components is 100%. The invention has the effects that the dosage of the water base lubricating agent used for eccentric wear prevention and added into the oil casing annular space of the oil well is 0.025-0.05%, the weight of the produced fluid of the oil well is 100%, hot wash cycle of the oil well is prolonged by more than 2 times, and the pump check cycle of the oil well is prolonged by more than 1 time.