The invention relates to the field of microbiology, in particular to a culture medium for producing synthetic probiotic groups through fermentation. The culture medium comprises the following ingredients in percentage by weight: 20 to 39 percent of bean dregs, 60 to 79 percent of wheat bran and 0.2 to 1 percent of mineral substance salts. The culture medium provided by the invention can maintain the stable propagation of the synthetic probiotic groups, can realize high-efficiency fermentation production, and simultaneously does not change functional metabolites of the synthetic probiotics.