The invention relates to a sobering up and liver protecting Chinese medicinal preparation and a preparation method thereof. The Chinese medicinal preparation comprises the following components in percentage by weight: 6 to 50 percent of kudzu vine flower, 6 to 40 percent of trifoliate orange seed, 1 to 18 percent of gynostemma pentaphylla, 1 to 18 percent of Citrus seed, 1 to 18 percent of licorice, 1 to 18 percent of cape jasmine, 3 to 18 percent of kudzu vine root and 3 to 18 percent of tuckahoe. The preparation method comprises the following steps of: crushing the kudzu vine flower, the trifoliate orange seed, the gynostemma pentaphylla, the Citrus seed, the licorice and the cape jasmine into coarse powder; adding water solution of polar organic solvent in the powder for extracting; merging the extract; filtering and performing decompression recovering on the solvent; and concentrating to obtain sobering up and liver protecting Chinese medicinal extractum, and adding the kudzu vineroot and the tuckahoe into the extractum to obtain a sobering up and liver protecting Chinese medicinal compound. The purpose of the method is to prepare the sobering up and liver protecting Chinese medicinal preparation safely, simply, reasonably and economically. The product has the advantages of relieving alcoholism, preventing drunkenness and preventing alcoholic liver injury, along with convenient taking, obvious curative effect, no toxic and side effect and the like and is particularly suitable for people who drink for a long time.