The invention relates to production material management system and method of a nuclear power plant. The system comprises a device ledger module, a maintenance outline module, a maintenance program module, a tool management module, a device type management module, a spare part management module, and the like. In the invention, a unified work platform system is formed, the works of query, treatment, and the like are greatly convenient, relationships are established among the modules, data is combined together in an organic mode, the problem of information isolated island is deracinated, data coherence is ensured, the system friendliness is strengthened, the problems of complex query operation are also solved, and the work efficiency is greatly improved.