The invention discloses a method for culturing Epinephelus coioides at a low salt degree, and relates to a culturing method for aquatic livestock, in particular to a method for culturing the Epinephelus coioides. The method comprises the following steps of: desalting sea water for culturing healthy Epinephelus coioides at a rate of decreasing 0.1 to 0.2 percent of salt degree per 24 hours; and when the salt degree is desalted to 0.8 percent, putting the Epinephelus coioides into a pond in which the salt degree of the water body is 0.8 percent for culturing, wherein the salt degree of the sea water is greater than 2.0 percent. By manually desalting and domesticating gradually, a pond culturing mode of the Epinephelus coioides is optimized so that the survival rate reaches over 70 percent. The yield of the Epinephelus coioides in each pot is over 150 kilograms; and the yield of the Epinephelus coioides of each mu of the pond is 500 kilograms.