The invention discloses a compound combined preparation for preventing osteoarticular pain and a preparation method thereof; the preparation comprises an active component glucosamine or combinations of more than one or two of the glucosamine and other active components chondroitin sulfate, dimethyl sulfoxide and collagen protein, and the glucosamine is glucosamine sulfate, hydrochloride, phosphate or the mixture thereof; and auxiliary materials comprise excipient, disintegration agent, lubricant, adhesive, stabilizer and wetting agent. The invention has good curing and preventing functions toinjury in arthritis and joint movement, the prepared tablets have the advantages of good disintegration performance, high dissolution speed and quick effect, the used amount of the raw materials and all the auxiliary materials reaches the best ratio, the product stability is improved, and the absorption utilization rate is high.