A manufacturing process of hollow glass square-hole bricks relates to a manufacturing method of building decoration materials. The invention is characterized by adopting the automatic process flow and realizing volume production of products. The manufacturing process mainly comprises the following working procedures: mold developing, pressing, molding by fusion welding, annealing and finished product inspecting, packaging and warehousing. The invention greatly reduces the labor intensity of workers, improves the yield of the round-hole bricks by about 5-6 times, saves the time of manual drilling, lowers the production cost and avoids the problems of irregularity of square holes on the glass bricks, high difficulty, burrs and the like in the process of manual manufacturing, thereby improving the product quality.