The invention discloses a denture for oral care and topical application of drug, belonging to the technical field of medical care instruments. The denture can be used for both upper teeth and lower teeth, and comprises a binding surface, a left end of the binding surface, a right end of the binding surface, an occlusal surface, an arc opening, an angular line and a reference line. The denture hassimple structure and convenient operation, can be used for topical application of drug for teeth, can serve as the carrier of a preparation for cleaning teeth stains, and can also be used for teeth protection (such as teeth protection in boxing) and prevention of teeth grinding. The denture avoids the problems of non sanitation and the like brought by complex operation of the existing denture, and is especially suitable for children.