The invention relates to an alumina-silicon nitride iron compound abrasive brick for a large-size cement kiln and a manufacture method thereof, belonging to the field of refractory materials. The alumina-silicon nitride iron compound abrasive brick is characterized in that superfine alumina clinker, silicon carbide and silicon nitride iron are used as main raw materials; the raw materials comprises the following components in percent by weight: 65-80 percent of the superfine alumina smaller than or equal to 5mm with an Al2O3 content not smaller than 85 percent, 5-15 percent of the silicon carbide smaller than or equal to 1.5mm with an SiC content not smaller than 90 percent, 1-15 percent of the silicon nitride iron smaller than or equal to 0.088mm with an Fe-Si3N4 content not smaller than 98 percent and 4-8 percent of bonding clay smaller than or equal to 0.088mm; 0.2-0.7 percent of industrial dextrin or lignin and 2-5 percent of water are added to the mixed raw materials for mulling, pressing and drying; and firing is carried out at 1,300-1,450 DEG C to prepare the alumina-silicon nitride iron compound abrasive brick. The product is suitable for various specifications of cement kilns, has obvious heat insulation effect, high abrasive resistance and long running time reaching longer than 1.5 years and has extremely positive effect on improving the running rate of a large-size rotary cement kiln, and the fired alumina-silicon nitride iron compound abrasive brick has simple process and low cost.