The invention discloses a centralized protection, measurement and control device which comprises the following functional plug-ins: a PowerPC board, a master control PowerPC board, a CPU board, a high-speed serial bus board and a liquid crystal display board, wherein the PowerPC board is arranged on the high-speed serial bus board by plug-in connection, comprises a sampling PowerPC board and receives a sampling packet from a merging unit or sent from the protection, measurement and control device through a sampling network on process level; the master control PowerPC board communicates with a background and a master controller through the network; the CPU board is arranged on the high-speed serial bus board by plug-in connection and used for realizing the data calculation and the protection function of all intervals; the high-speed serial bus board is an access board for all the plug-ins and used for data transmission among the plug-ins; and the liquid crystal display board is connected with the master control PowerPC board through a built-in network port. The device can reduce the complex wiring among all the intervals on the secondary side of a substation and reduce the work of design, manufacture and maintenance of secondary equipment of an automatic system of the substation.