The invention relates to a health-care wine, which is prepared from the following raw materials in weight proportion: 4,000 to 5,000 of Chinese spirit, 80 to 120 of honey, 65 to 80 of raidx astragali, 65 to 85 of largehead atractylodes rhizome, 60 to 80 of poria, 50 to 70 of epimedium herb, 60 to 80 of white paeony root, 60 to 80 of common macrocarpium fruit, 30 to 45 of pseudo-ginseng, 35 to 50 of divaricate saposhnikovia root, 10 to 20 of nardostachyos root and rhizome and 15 to 25 of grassleaf sweelflag rhizome. A preparation method of the health-care wine comprises the following steps: weighing raidx astragali, largehead atractylodes rhizome, poria, epimedium herb, white paeony root, common macrocarpium fruit, pseudo-ginseng, divaricate saposhnikovia root, nardostachyos root and rhizome and grassleaf sweelflag rhizome in weight proportion; then grinding the raw materials into fine powder; soaking the fine powder into the Chinese spirit in weight proportion; after the color of solution of medicated wine is not changed, filtering the solution of the medicated wine; simultaneously adding the honey in weight proportion; and completing preparation until precipitate cannot be seen by naked eyes in wine solution, wherein the wine solution can be drunk. The health-care wine has simple preapration, has rich active ingredients of traditional Chinese medicine, has precise formula, improves material metabolism in the human body, strengthens immunity of the human body and has obvious health-care effect.