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发明授权
CN101845425B 一种α-半乳糖苷酶及其表达、纯化方法 有权

一种α-半乳糖苷酶及其表达、纯化方法
摘要：
本发明公开了一种α-半乳糖苷酶及其表达、纯化方法。该α-半乳糖苷酶由序列表中的SEQ ID NO：1表示，由脆弱类杆菌(Bacteriodes fragilis)ATCC25285的重组基因组DNA序列SEQ ID NO：3编码得到，为具有将人红细胞血型由B型转变为O型、由AB型转变为A型作用的蛋白质。本发明的α-半乳糖苷酶用途广泛，表达及纯化方法简便、成本低廉，具有重要的临床及科学研究意义，市场前景广阔。
摘要（英）：

The invention discloses an alpha-galactosidase and an expression and purification method thereof. The alpha-galactosidase is expressed by SEQ ID NO:1 in a sequence table, is obtained by encoding a recombinant genome DNA sequence SEQ ID NO:3 of bacteroides fragilis (Bacteroides fragilis) ATCC25285 and is a protein with effect of converting a red cell blood group of the human body from B-type into O-type and from AB-type into A-type. The alpha-galactosidase of the invention has the advantages of wide application, simple and convenient expression and purification method, low cost, important clinical and scientific research significance and wide market prospect.

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