The invention discloses a high-vacuum fluorine-lined device, which has the advantages that the structure is simple, the use effect is good, the service life is long and the device can be normally used under strong-corrosion, high-temperature and high-vacuum conditions, and solves the technical problems existing in the prior art that a fluorine lining layer is apt to bubble and fall off when the high-vacuum fluorine-lined device is used under high-temperature and high-vacuum conditions, frequent maintenance and repair equipment are required, the service life of the device is reduced, the production efficiency is reduced, the production cost is improved and the like. The device comprises a sealing structure connected with a vacuum system. An anticorrosive fluorine lining layer is arranged on the inner wall of the sealing structure. An adsorption chamber is arranged between the fluorine lining layer and the inner wall of the sealing structure. The adsorption chamber is communicated with an additional vacuum system outside the sealing structure through an adsorption chamber exhaust port on the sealing structure.