The invention discloses a novel nicotine pesticide combination containing 1-[(6-Chloropyridin-3-yl)methyl]-7- methyl-8-nitro-5-propoxy-1,2,3,5,6,7-hexahydroimidazo [1,2-Alpha] pyridine. The active components of the combination are 1-[(6-Chloropyridin-3-yl)methyl]-7- methyl-8-nitro-5-propoxy-1,2,3,5,6,7-hexahydroimidazo [1,2-Alpha] pyridine and novel nicotine pesticide, the novel nicotine pesticide is imidacloprid, acetaniprid, thiamethoxam, thiacloprid or nitenpyram, and the weight ratio of 1-[(6-Chloropyridin-3-yl)methyl]-7- methyl-8-nitro-5-propoxy-1,2,3,5,6,7-hexahydroimidazo [1,2-Alpha] pyridine to the novel nicotine pesticide is 1:60 to 15:1. Compared with the single agent, the combination has a remarkable synergistic effect, consequently, the application cost is reduced, the resistance to 1-[(6-Chloropyridin-3-yl)methyl]-7- methyl-8-nitro-5-propoxy-1,2,3,5,6,7-hexahydroimidazo [1,2-Alpha] pyridine can be delayed, and the problem of resistance to the conventional novel nicotine pesticides can be solved to a certain extend.