The invention discloses arginine (s)-ibuprofen granules which are prepared from the following raw materials in parts by weight: 1 part of arginine (s)-ibuprofen, 1-100 parts of fillers, 1-20 parts of adhesives, 0.2-10 parts of thickening agents and 0.1-10 parts of flavoring agents. The granules are quickly dissolved in water to form transparent liquid with good mouthfeel, are convenient to take and have high bioavailability. The preparation method is simple, dispenses with any special equipment and is suitable for industrial production.