The invention discloses a construction method for preventing vertical cracking between a main structure and a filled wall. After the construction of the main structure is finished, the construction of the filled wall is implemented; when the filled wall is constructed, the side surface of the filled wall in connection with the main structure is made into a zigzag structure; a tension rib in the filled wall penetrates a reserved combination column space to be connected with the main structure at the side surface; a combination column template is supported at the reserved combination column space, and plain concrete is poured and vibrated tightly to form a combination column; and the filled wall and the main structure are connected as a whole through the combination column. The plain concrete combination column is poured between the side surface of the filled wall and the main structure, and the combination column is connected with the main structure through the same material and engaged with the filled wall through the zigzag structure, therefore, the problem of cracking caused by insufficient engaging force between the main concrete structure and the filled wall and the shrinkage of the dissimilar materials of the wall is successfully solved; meanwhile, the combination column can effectively adjust the line snapping size and reduce the loss rate of the building blocks.