The invention relates to new application of a fluoroquinolone compound comprising a 7-(3-amino-4-oximido)-1-piperidyl substitutional group, in particular to application of 1-cyclopropyl-6-flurine-8-methoxyl-7-[(3-amino-4-methyl/ethyl oximido) piperidyl-1-group]-1,4-dihydro-4-oxo quinoline-3-carboxylic acid, or medicinal salt, hydrate and composition thereof in curing tuberculosis. Compared with the conventional clinic first-line antitubercular medicament (such as rifampicin) and a second-line antitubercular fluoroquinolones medicament (such as ciprofloxacin and the like), the fluoroquinolone compound has more excellent antitubercular mycobacteria activity.