The invention belongs to the technical field of medicines for preventing hypertension, and provides a nitric oxide donating thienopyridine derivative with a structure with a formula I, and salt thereof, wherein R1, R2 and R3 are simultaneously or respectively hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy and nitro; and R4 is C1-C6 straight-chain or branched-chain alkyl. The invention also relates to a preparation method of the compound, and simultaneously, discloses a medicine compound which takes the compound or the pharmaceutically acceptable salt thereof as an active effective constituent, and the application of the medicine compound as the medicine for preventing hypertension.