The invention relates to a cluster-based distributed antenna time frequency synchronizing method in wireless communication, and belongs to the technical field of wireless communication. The method comprises the following steps of: dividing mass distributed antennas into clusters, selecting cluster representative antennas, and performing distributed bidirectional coordinated synchronization on thecluster representative antennas; and then, initiating intra-cluster distributed bidirectional coordinated synchronization by the cluster representative antennas so as to finally realize time frequency synchronization of all distributed antennas in a system. The method has the following advantages that: through cluster division, a plurality of clusters are simultaneously synchronized, the total synchronization time is reduced and the synchronization speed is quickened; the synchronization between the cluster representative antennas is performed first and then the intra-cluster distributed bidirectional coordinated synchronization is performed so as to obtain higher synchronization precision and meet the requirement of a distributed wireless communication system for synchronization precision; and the synchronization between the distributed antennas is finished in advance so as to avoid multiple times of synchronization between a terminal user and a plurality of distributed antennas. Themethod reduces the system resource overhead of the terminal user, and improves the communication reliability.