The invention provides a cross angle-cleaning machine for plastic doors and windows, comprising a frame, a nose seat, noses, a nose positioning device and a workpiece fixing device. The machine is characterized in that a nose component is formed by four noses, the nose seat and a linking mechanism; four pairs of radial sliding rails are uniformly arranged on the nose seat along the circumference, and each nose is slidably arranged on a pair of sliding rails through a chute on the bottom end; the linking mechanism capable of driving the noses to simultaneously translate along the sliding rail passes through the bottom ends of the four noses; workbenches for supporting workpieces is arranged among the four noses, are vertical to one another, and are connected on the nose seat. The machine has the advantages that: the four noses are connected by using the linking mechanism, after the workpieces are fixed on the workbenches, cross and V-shaped overlaps on the workpieces can be removed by using various tools of the four noses without changing the workpieces for multiple times, so that the working efficiency can be greatly improved.