The invention discloses a method for carrying out well design by using time-lapse seismic, which comprises the following steps: 1) respectively obtaining seismic data of two different time points according to methods of the step a and the step b: a. detecting the stratum basic parameters of a region to be detected, manufacturing an oil deposit profile of the region to be detected, establishing a stratum profile module according to the oil deposit profile, and obtaining three data bodies: the longitudinal wave speed, the transverse wave speed and the density according to the stratum basic parameters and the stratum profile module; and b. carrying out AVO forward modeling to obtain the overlapped seismic data of each incidence angle; 2) processing the seismic data in the two times to obtainseismic data difference; 3) carrying out reversion on the seismic data difference to obtain longitudinal wave difference, transverse wave difference, density difference and longitudinal and transverse wave speed ratio difference; 4) predicting the oil deposit parameter change; and 5) carrying out well design. The invention forms the difference reversion based on the time-lapse seismic for realizing the oil deposit parameter change prediction process and determining the well design, and the goal can not be realized by using conventional methods.