The invention relates to a multifunctional measurement and control module based on a field bus, comprising a multi-path selection module, a signal conditioning module, an isolating and amplifying circuit, an A/D conversion and control module that are sequentially connected. An acquiring signal is input into the multi-path selecting module, then conditioned and converted by the signal conditioningmodule, sent to the isolating and amplifying module for isolation and amplification, and enters the A/D conversion and control module; a simulating signal is converted into a digital signal by the A/D conversion; and a signal processed by the control module is output by a communication interface with field bus function. By matching the multi-path selecting module with the signal conditioning module, each channel can access a plurality of signals, can be matched with a programmable amplifier by the introduction of a high-accuracy reference voltage, and can be used for measuring the current real amplification factor, thereby eliminating the drift caused by the null drift of the amplifying module.