The invention relates to a medicine for developing a dopamine transporter and a preparation method thereof. The medicine has the structure described in the specification, wherein X= -CH2 or -C=O, and R=Br or F18. Novel serial 2 beta amide/amino-3 beta chlorobenzene tropine derivatives containing pyridine groups are designed and synthesized by using 2 beta-carboxyl-3beta chlorobenzene tropine as alead compound, have higher targeting, can be specifically combined with DAT, can be used for marking F-18 by introducing a pyridine ring structure, can be used for carrying out PET development research, and are PD diagnosis developer with favorable application potential.