The invention relates to a brake of a high-speed heavy-load vehicle, which has the structure capable of providing a torque enabling the vehicle to stop at maximum speed, enabling the vehicle to be continuously on a slope of 60 percent, meeting the requirements on a high-power heavy-load high-speed vehicle and conveniently enhancing the maneuvering performance of the vehicle. The brake of the high-speed heavy-load vehicle comprises a connecting disc assembly with a C/SiC friction lining, a braking disk assembly with a C/SiC friction lining, a press plate assembly with a C/SiC friction lining, a movable wheel ball bearing, a rotational wheel ball bearing assembly, a spring, the C/SiC friction linings, an insulating plate, a roller, a supporting roller, a connecting disk, a flat key, a spring and an involute positioning block, wherein the spring is used for enabling the movable wheel ball bearing assembly to be reset; the roller provides the axial movement of the movable wheel ball bearing; and the spring is used for enabling a rotational wheel ball bearing to be reset. The invention can ensure that the service life of the brake is greatly prolonged and the braking torque and the reliability of the brake are greatly enhanced, has excellent performance and good reliability and is suitable for batch production.