The invention relates to a wireless blood cold chain and informatization management system and a method. A ZigBee network transmits an encrypted blood bag tag message to a ZigBee network coordinator, an ARM controller controls a GPRS remote transmitter to transmit the message out, a GPRS receiving module in a network core central blood station receives and decrypts the message and transmits the message to a database server for storage, and a couple of superintend departments check the messages in the database server in a remote manner via internet by means of corresponding permissions. The system has low cost, low complexity and high efficiency, realizes normalization, informatization and standardization for clinic transfusion supervision, and achieves remote and real-time informatization accurate supervision containing the blood cold chain supervision.