The invention discloses a reishi sporule powder high-yield cultivating method, which belongs to the technical field of edible and medical fungi, which is characterized by comprises: (1) a process step of reishi strain selection, in which a high-quality strain which is high in sporule powder yield, quality and disease resistance is selected; (2) a process step of cultivation environment selection,in which a mountain area with a daily average temperature of more than or equal to 10 DEG C, an annual effective accumulated temperature of more than 5,700 DEG C and annual rainfall of 1,650 millimeters is selected; (3) a process step of culture medium tree seed selection, in which fagaceae tree seeds are used as a culture medium; (4) a process step of bagged and sleeved cultivation time determination, in which the sporule powder cultivation lasts for 111 to 142 days from the day when bagging and sleeving are performed; and (5) a process step of harvesting, in which the sporule powder is harvested every 20 days from the day when the bagged and sleeved cultivation of the fruit bodies of the reishi starts. In the invention, the dry weight ratio of the cultivated and harvested reishi sporulepowder to the yield of the fruit bodies is 134.08 to 185.5 percent. Compared with the prior art, the method improves the yield by 6 times, cultivates high purity and quality reishi sporule powder, reduces cost and increases sales income sales revenue by 130 percent.