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发明授权
CN101891633B 2-氯-5-硝基-1,4-对苯二胺的制备方法 失效 - 权利终止

2-氯-5-硝基-1,4-对苯二胺的制备方法
摘要：
本发明提供了2-氯-5-硝基-1，4-对苯二胺的制备方法，其是以2-氯-1，4-对苯二胺硫酸盐I为反应起始物，通过化学反应得到N1，N4-二三氟乙酰基-2-氯-对苯二胺II，II在浓硝酸的作用下得到N1，N4-二三氟乙酰基-2-氯-5-硝基-对苯二胺III，最后，III在弱碱的作用下脱除保护基，得到目标产物2-氯-5-硝基-1，4-对苯二胺IV。采用本发明方法制备2-氯-5-硝基-1，4-对苯二胺，节约了浓硝酸的使用量，不产生废酸，对环境友好，产率可达50-60％，反应可以放大。
摘要（英）：

The invention provides a preparation method of 2-chlorine-5-nitro-1,4-p-phenylenediamine, comprising the following steps of: using 2-chlorine-1,4-p-phenylenediamine sulfate I as the reaction initiator to obtain N1,N4-bis(trifluoroacetyl)-2-chlorine-p-phenylenediamine II through chemical reaction, obtaining N1,N4-bis(trifluoroacetyl)-2-chlorine-5-nitro-p-phenylenediamine III under the action of concentrated nitric acid, and finally, desorbing protective group under the action of weak base to obtain the target output of 2-chlorine-5-nitro-1,4-p-phenylenediamine IV. The preparation method of 2-chlorine-5-nitro-1,4-p-phenylenediamine saves the use amount of concentrated nitric acid without producing waste acid, is environmentally-friendly, has the yield as high as 50-60% and can magnify the reaction.

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