Aspects of the invention may comprise calibrating operations of wireless transmitters and/or receivers in a communication device to mitigate interference caused during concurrent communications via the wireless interfaces in the communication device. Calibration may be performed dynamically, and may comprise managing system parameters and/or physical resources of the communication device and/or the wireless transmitters and/or receivers; managing characteristics of wireless communication performed via the wireless transmitters and/or receivers; and/or managing isolation between two or more of said plurality of wireless transmitters and/or receivers in said communication device. The calibration may be performed based on data generated, via the wireless transmitters and/or receivers, during active and/or idle phases of operations. The data may be based on monitoring of RF effects caused by operations of other wireless transmitters and/or receivers. A coexistence manager may exchange data and/or control signaling with the wireless transmitters and/or receivers during to performing the calibration.