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发明授权
CN101899090B 饱和脂肪链醇His-Gly-AA三肽酯及其合成方法和应用 失效 - 权利终止

饱和脂肪链醇His-Gly-AA三肽酯及其合成方法和应用
摘要：
本发明涉及通式I的12种具有免疫抑制活性的饱和脂肪链醇His-Gly-AA三肽酯缀合物，其中AA为Glu或Lys，饱和脂肪链醇中n＝6、8、10、12、14或16，涉及它们的制备方法以及作为免疫抑制剂的应用。这些饱和脂肪链醇His-Gly-AA三肽酯对脾淋巴细胞丝裂原增殖反应的抑制作用，以及对巨噬细胞吞噬活性的抑制作用的实验结果表明，本发明的化合物具有优秀的免疫抑制作用，临床上可作为免疫抑制剂应用。His-Gly-AA-O-CH2-(CH2)nCH3 I
摘要（英）：

The invention relates to 12 saturated fatty chain alcohol His-Gly-AA tripeptide ester conjugates with immunosuppressive activity in a general formula His-Gly-AA-O-CH2-(CH2)nCH3 I, wherein AA stands for Glu or Lys. In saturated fatty chain alcohol, n is equal to 6, 8, 10, 12, 14 or 16. the invention also relates to a preparation method and application of the conjugates as an immunosuppressant. An experimental result of the saturated fatty chain alcohol His-Gly-AA tripeptide ester which has the inhibition effects of splenic lymphocyte mitogen breeder reaction and macrophage phagocytosis activity indicates that the conjugates of the invention have excellent immunosuppressive action and can be clinically used as an immunosuppressant.

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