The present invention discloses a calculus-dissolving medicament. The medicament is prepared from the following raw materials in part by weight: 60 to 100 parts of lysimachia, 90 to 150 parts of glechoma longituba, 15 to 50 parts of berchemia lineata, 5 to 15 parts of rhizoma alismatis, 30 to 90 parts of sunflower root, 15 to 50 pats of orthosiphon, 5 to 15 parts of szechwan Chinaberry fruit, 3 to 9 parts of liquorice root, 5 to 18 parts of ground beetle, 10 to 30 parts of sea-ear shell, 9 to 12 parts of myrmeleon formicarius linnaeus, 7 to 25 parts of cattail pollen and 10 to 30 parts of lalang grass rhizome. Compared with the prior art, the calculus-dissolving medicament of the invention has the advantages that: the lysimachia and the glechoma longituba serve as main medicaments, and the other 11 auxiliary medicaments are added to interact with the main medicaments and produce a synergistic effect with the main ingredients, good effect of dissolving and discharging calculus can be achieved, safety is ensured, toxic and side effects are avoided, the treatment course is short, quick response is made, high effectiveness is achieved, and the effective rate can be over 95 percent; and good effect of dissolving and discharging calculus on hepatic calculus, renal calculus, vesical calculus, urinary calculus and the like can be achieved.