The invention discloses an open ratchet two-purpose wrench groove milling clamp, which can perform clamping and fixing conveniently. The clamp comprises a bottom plate, wherein a frame is arranged on the bottom plate; a fixed jaw is reserved on the frame; a groove matched with the handle of an open ratchet two-purpose wrench is formed on the jaw; a sliding block is arranged on one side of the groove; the sliding block is connected with one end of an adjusting screw arranged on the frame; an adjusting hand wheel is arranged on the other end of the adjusting screw; a pressing block matched withthe groove is arranged above the groove; the pressing block is arranged on a movable jaw connected with the piston of a hydraulic cylinder arranged on the upper end of the frame fixedly; a lower bracket is fixedly arranged on one side of the frame; the adjusting screw is arranged on the lower bracket through an adjusting nut; and the end part of the adjusting screw is pressed against an open wrench head on one end of the handle of the open ratchet two-purpose wrench.