The invention discloses a thiazolyl acrylonitrile ester compound, a preparation method and application thereof, belonging to the technical filed of medicines. The preparation method comprises the following steps: carrying out esterification on a compound shown in a formula (II) and acyl chloride shown in a formula (III) in a protonic or non-protonic organic solvent under the action of acid-catcher at 60-160DEG C for 1-20h to obtain reaction liquid; and then postprocessing the reaction liquid to obtain the compound. The compound obtained in the invention can be used as phytocide and phytotoxin, and keeps the advantages of high efficiency, low toxic, safety and environment-friendly of the thiazolyl acrylonitrile compound, and increases new applicable substances for the development of new pesticide.