The invention discloses a major-diameter prestressed concrete pipe pile of a glass steel pipe die. A concrete lining is arraigned in a glass steel pipe external die; a reinforcement cage consisting of a prestressed longitudinal bar and a spiral stirrup is arranged in the concrete lining; and a steel end plate and a steel plate inside band are arranged at two ends of the pile. An assembled multi-section steel sleeve working component for temporarily bearing prestressing stretch-draw anchoring force is arranged on the periphery to temporarily wrap the glass steel pipe external die, a gap between the steel sleeve working component and the glass steel pipe external die is tightly wedged by using a wooden triangular block; the steel sleeve working component bears the stretch-draw anchoring force of the prestressed longitudinal bar; and a centrifugal machine rotates the steel sleeve working component to drive the glass steel pipe external die to rotate. The major-diameter prestressed concrete pipe pile with arbitrary pile body length can be manufactured on site, and overcomes the defects that the conventional major-diameter pre-tensioning method prestressed concrete pipe pile has fixed pile body length, an over-long pipe pile is difficult for long-distance transportation, a prestressed reinforcement is easy to be rusted and is easy to be cracked during transportation and hoisting, and the like.