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发明公开
CN101910190A 17-羟基-19-去甲-21-羧酸类固醇γ-内酯衍生物、其用途及包含所述衍生物的药品 无效 - 撤回

17-羟基-19-去甲-21-羧酸类固醇γ-内酯衍生物、其用途及包含所述衍生物的药品
摘要：
本发明涉及具有化学式(1)的17-羟基-19-去甲-21-羧酸类固醇γ-内酯衍生物及其溶剂合物、水合物、立体异构体和盐，其中，基团R4、R6a、R6b、R7、R15、R16a、R16b、R18和Z具有权利要求1给出的指定。本发明还涉及所述衍生物用于制备用于口服避孕和治疗绝经前、围绝经期和绝经后疾病的药品的用途，还涉及含有所述衍生物的药品。本发明的衍生物具有促孕作用，而且在优选的情况中还具有抗盐皮质激素作用和中度至轻度的雄激素作用。
摘要（英）：

The invention relates to 17-hydroxy-19-nor-21-carboxylic acid-steroid gamma-lactone derivatives with the chemical formula (1) wherein R4, R6a, R6b, R7, R15, R16a, R16b, R18 and Z have the designations given in claim 1, and to the solvates, hydrates, stereoisomers and salts thereof. The invention also relates to the use of said derivatives for producing a medicament for oral contraception and for the treatment of premenopausal, perimenopausal and postmenopausal troubles, and medicaments containing said derivatives. The derivatives according to the invention have a gestagen effect, and in preferred cases, also an anti-mineral corticoid and neutral to lightly androgenous effect.

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