The present invention provides for microfluidic devices and methods for their use. In one embodiment, a microfluidic system comprises the following components: a receiving station which is suitable for receiving microfluidic equipment with a plurality chambers, while the microfluidic equipment is connected with a carrier, and at least some chambers in the plurality of chambers is connected with a plurality of inlets in the carrier; an interface plate which is suitable for being jointed with at least one inlet in the carrier; a fluid source which is connected with the interface plate and is suitable for providing pressure fluid for at least one inlet in the carrier; and a controller which is connected with the fluid source and the interface plate for guiding the fluid from the fluid source to the carrier.